Polynucleotide Treatment in Knightsbridge -- What You Need to Know
If you have been researching skin rejuvenation treatments in London, you may have come across polynucleotides – a newer injectable treatment gaining attention for its ability to improve skin quality from within. But what exactly are polynucleotides, how do they work, and are they right for you?
This guide covers everything you need to know about polynucleotide treatment at our Knightsbridge clinic.
What Are Polynucleotides?
Polynucleotides are chains of nucleotides – the building blocks of DNA and RNA. In aesthetic medicine, they are derived from purified fish DNA (typically salmon or trout) and injected into the skin to stimulate tissue regeneration.
Unlike dermal fillers that add volume, or Profhilo that remodels skin through hyaluronic acid, polynucleotides work at a cellular level. They trigger fibroblast activity, boost collagen production, and improve the skin’s natural repair mechanisms. The result is healthier, more resilient skin – not a “filled” look.
How Does Polynucleotide Treatment Work?
The treatment involves a series of small injections into the target area. The polynucleotide gel creates a scaffold that supports cell growth and tissue repair. Over the following weeks, your skin responds by:
- Increasing collagen and elastin production
- Improving hydration at a cellular level
- Strengthening the extracellular matrix
- Reducing oxidative stress and inflammation
A typical course involves 2-3 sessions spaced 2-3 weeks apart, with results building gradually over 6-12 weeks.
What Can Polynucleotides Treat?
Polynucleotide treatment is particularly effective for:
- Under-eye area: Dark circles, crepey skin, fine lines
- Full face: Overall skin quality improvement, dullness
- Neck: Crepiness, early signs of ageing
- Hands: Thin, aged skin
- Acne scarring: Improved skin texture and healing
It is not a replacement for dermal fillers in areas where you need structural volume (cheeks, lips, jawline). Think of polynucleotides as improving the quality of your skin canvas, while fillers reshape and volumise.
Polynucleotides vs Profhilo – What Is the Difference?
This is the most common question we get asked. Both are injectable skin boosters, but they work differently:
Profhilo uses high-concentration hyaluronic acid to remodel skin through a bio-remodelling effect. It spreads widely after injection and is excellent for laxity and hydration across larger areas. Two sessions, one month apart.
Polynucleotides work at the cellular level to regenerate tissue. They are more targeted, better for specific problem areas (especially under-eyes), and have a stronger anti-inflammatory effect. Typically 2-3 sessions.
Many patients benefit from both – Profhilo for overall skin remodelling, polynucleotides for targeted regeneration in delicate areas. Our Knightsbridge practitioner can advise on the best approach for your skin during a consultation.
What to Expect During Treatment
A polynucleotide session at our Knightsbridge clinic typically takes 30-45 minutes:
- Consultation: Your practitioner assesses your skin and discusses goals
- Cleanse: The treatment area is cleaned thoroughly
- Numbing: A topical anaesthetic is applied if needed (the under-eye area can be sensitive)
- Injection: Small amounts of polynucleotide gel are injected using a fine needle or cannula
- Aftercare: You may see small bumps at injection sites that settle within 24-48 hours
Most patients describe mild discomfort. Bruising is possible but usually minimal and easily covered.
Is There Any Downtime?
Polynucleotide treatment has minimal downtime. You can expect:
- Small bumps at injection sites (settle within 24-48 hours)
- Possible mild bruising (especially under the eyes)
- Slight redness at injection points
Most patients return to normal activities the same day. We recommend avoiding strenuous exercise, alcohol, and excessive heat for 24 hours after treatment.
How Long Do Results Last?
Results from a full course of polynucleotide treatment typically last 6-9 months. Maintenance sessions every 6 months help sustain results. The skin continues to improve for several weeks after the final session as collagen production ramps up.
Is Polynucleotide Treatment Safe?
Polynucleotides have an excellent safety profile. They are biocompatible (derived from natural DNA), biodegradable, and do not cause allergic reactions in most patients. The treatment has been used in regenerative medicine for decades before entering the aesthetics field.
Common side effects are limited to injection-site reactions: redness, swelling, mild bruising. These resolve within days.
As with any injectable treatment, it should only be performed by a qualified medical practitioner in a clinical setting.
Who Is a Good Candidate?
Polynucleotide treatment is suitable for most adults concerned about skin quality rather than volume loss. It is particularly beneficial if you have:
- Dull, tired-looking skin
- Fine lines and crepiness
- Dark circles or hollow under-eyes
- Acne scarring or uneven texture
- Early signs of ageing you want to address proactively
It is not recommended during pregnancy or breastfeeding, or if you have active infections in the treatment area.
Book a Polynucleotide Consultation in Knightsbridge
If you are considering polynucleotide treatment in London, our Knightsbridge clinic offers consultations to assess your skin and create a personalised treatment plan. Every treatment is performed by a qualified medical practitioner in a clinical environment.
Book a consultation at our Knightsbridge clinic, or explore our other skin rejuvenation treatments including Profhilo and PRP treatment.